Sorry, no online dictionaries contain the exact phrase despondency and irritation.
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Reverse dictionary results:
1. solace
2. woe
3. blahs
4. console
5. gloomy
6. grim
7. blue
8. cheering
9. cheers
10. gri
11. annoy
12. dammit
13. damn
14. darn
15. galling
16. huff
17. huffing
18. nettlesome
19. pain
20. shucks
21. sore
22. thorn
23. vexation
24. vexatious
25. adversity
26. afflicted
27. aggrieve
28. ail
29. anger
30. angered
31. bedevil
32. bollocks
33. bugger
34. cark
35. chagrin
36. comfort
37. concern
38. consternate
39. consternation
40. cru

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You can look up the words in the phrase individually using these links:   despondency ?   and ?   irritation ?
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