Sorry, no online dictionaries contain the exact phrase defeat with mental acumen.
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Reverse dictionary results:
1. outsmart
2. outwit
3. outthink
4. outmaneuver
5. outplay
6. outpray
7. outpreach
8. outprize
9. outpromise
10. outsee
11. outwrite
12. overcome
13. amazon
14. lord it over
15. outcode
16. outdoing
17. outgame
18. outgive
19. outman
20. outrank
21. outreach
22. outscore
23. talk out
24. excel
25. force
26. get the better of
27. outbrave
28. outclass
29. outcompete
30. outdance
31. outdo
32. outduel
33. outgeneral
34. outlie
35. outlook
36. outmarch
37. outmatch
38. outperform

You can look up the words in the phrase individually using these links:   defeat ?   with ?   mental ?   acumen ?
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