Sorry, no online dictionaries contain the exact phrase causes great anguish.
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Reverse dictionary results:
1. torment
2. suffering
3. distress
4. agony
5. anguishing
6. sufferation
7. afflicted
8. agonic
9. agonizing
10. ail
11. anguish
12. anguished
13. bale
14. calamitously
15. depressed
16. depressing
17. diseaseful
18. distressful
19. distressing
20. dolor
21. doloriferous
22. dolorific
23. doloroso
24. dolour
25. grief
26. griefful
27. grieving
28. grievous
29. harrowing
30. heartache
31. heartbreak
32. heartbreaker
33. heartbreaking
34. heartrending
35. heartsick
36. heartwrenching
37. hurtingly
38. irritating
39. martyrdom

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You can look up the words in the phrase individually using these links:   causes ?   great ?   anguish ?
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