Sorry, no online dictionaries contain the exact phrase breathe with great difficulty.
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Reverse dictionary results:
1. choke
2. smothering
3. smothered
4. choked
5. wheeze
6. breathless
7. pant
8. gasp
9. snuffle
10. gum
11. mumble
12. puff
13. gummed
14. gumming
15. corner
16. billow
17. stagger
18. difficult
19. ease
20. hard
21. hardly
22. make
23. strain
24. pry
25. trouble
26. land
27. scrape
28. staggered
29. staggering
30. tree
31. treed
32. winning
33. dyspneal
34. dyspneic
35. dyspnoeal
36. dyspnoeic
37. flounder
38. cornered
39. cornering
40. inaccessible

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You can look up the words in the phrase individually using these links:   breathe ?   with ?   great ?   difficulty ?
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brea*to search for words beginning with brea, or
*ultyto search for words ending with ulty
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