Sorry, no online dictionaries contain the exact phrase biggest setback.
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Reverse dictionary results:
1. africa
2. australia
3. laid
4. loser
5. meridian
6. saskatoon
7. top
8. beth
9. bath
10. blow
11. catastrophe
12. decline
13. jolt
14. one
15. relapse
16. retreat
17. smack
18. waterloo
19. aaron
20. achoerodus gouldii
21. adam
22. affliction
23. aftershock
24. aggravation
25. agranulocytosis
26. air
27. airs
28. alcove
29. also-ran
30. alternate
31. alternating
32. amoy
33. amputation
34. ant
35. antecede
36. antedate
37. anterior
38. aphaeresis
39. apocope
40. appall

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You can look up the words in the phrase individually using these links:   biggest ?   setback ?
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