Sorry, no online dictionaries contain the exact phrase take up challenge.
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Reverse dictionary results:
1. gauntlet
 2. swallow
3. scoop
4. embrace
5. dare
6. defend
7. question
8. questioning
9. questions
10. flush
 11. reconsider
12. pick
13. rise
14. undertake
15. take up
16. assume
17. tape
18. bear
19. charge
20. come
 21. confront
22. draw
23. stay
24. tackle
25. pass
26. overcome
27. passed
28. retire
29. settle
30. lift
 31. anticipate
32. borrow
33. dip
34. enter
35. hit
36. renew
37. stand
38. raise
39. accept
40. fill

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You can look up the words in the phrase individually using these links:   take ?   up ?   challenge ?
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