Sorry, no online dictionaries contain the exact phrase significant number.
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Reverse dictionary results:
1. substantial
2. considerable
3. sizable
4. meaningful
5. notable
6. importance
7. pivotal
8. significant
9. significative
10. concerning
11. consequential
12. decent
13. historic
14. key
15. major
16. material
17. mightly
18. pertinent
19. potency
20. potent
21. predominantly
22. superimportant
23. vital
24. all-important
25. central
26. critical
27. important
28. instrumental
29. measurable
30. pitch
31. powerful
32. predominant
33. preponderatingly
34. prominency
35. red-letter
36. relevant
37. strong point

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