Sorry, no online dictionaries contain the exact phrase significant issue.
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Reverse dictionary results:
1. important
 2. crucial
3. critical
4. pressing
5. paramount
6. preponderatingly
7. concerning
8. consequential
9. considerable
10. decent
 11. importance
12. key
13. major
14. overarchingly
15. pertinent
16. pivotal
17. potency
18. potente
19. potentiary
20. powerful
 21. preponderant
22. prepotent
23. prevailing
24. significant
25. significative
26. vital
27. appreciably
28. bellipotent
29. central
30. cogent
 31. considerably
32. dominant
33. instrumental
34. meaningful
35. mighte
36. of the essence
37. potence

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