Sorry, no online dictionaries contain the exact phrase significant change.
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Reverse dictionary results:
1. transformation
 2. alteration
3. shift
4. modification
5. transition
6. altering
7. changer
8. modify
9. permutate
10. alter
 11. amended
12. change
13. evolve
14. modified
15. mutandum
16. mutate
17. subsample
18. amend
19. conversion
20. convert
 21. transmutation
22. adjust
23. changing
24. chaunge
25. chg
26. commutate
27. distribute
28. mod
29. update
30. adjustment
 31. calibration
32. decompound
33. distributary
34. distribution
35. edited
36. integrate
37. modulate

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