Sorry, no online dictionaries contain the exact phrase make informed guess.
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Reverse dictionary results:
1. hypothesize
2. conjecture
3. autonomy
4. divine
5. surmise
6. estimate
7. decide
8. deciding
9. divined
10. guessing
11. perfect
12. perfected
13. perfecting
14. bet
15. bets
16. betting
17. brt
18. imagine
19. imagining
20. sphinx
21. knowledge
22. discovered
23. learn
24. speculate
25. estimation
26. know
27. notice
28. read
29. judgment
30. stab
31. guesstimate
32. divination
33. appraisal
34. announce
35. bumble
36. burr
37. can
38. cognize
39. confuse
40. consider

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You can look up the words in the phrase individually using these links:   make ?   informed ?   guess ?
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