Sorry, no online dictionaries contain the exact phrase major route.
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Reverse dictionary results:
1. artery
2. highway
3. thoroughfare
4. main road
5. expressway
6. access road
7. arterial
8. arterial road
9. autoroute
10. beeline
11. belt loop
12. beltline
13. beltway
14. bus lane
15. bylane
16. carpool lane
17. carriageway
18. central reservation
19. corridor
20. diamond lane
21. divided highway
22. dogleg
23. dualling
24. express lane
25. expwy
26. expy
27. freeway
28. high road
29. high street
30. interstate
31. lane
32. laned
33. loop
34. motorway
35. neutral ground
36. parkway
37. rd

You can look up the words in the phrase individually using these links:   major ?   route ?
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majo*to search for words beginning with majo, or
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