Sorry, no online dictionaries contain the exact phrase main issue.
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Reverse dictionary results:
1. primary concern
 2. central problem
3. key focus
4. core issue
5. fundamental matter
6. substance
7. background
8. essence
9. essentials
10. important
 11. priority
12. theme
13. themes
14. red herring
15. sidetrack
16. collateral
17. joke
18. jokes
19. rider
20. argument
 21. arm
22. aspect
23. back
24. bak
25. basic
26. bond
27. book
28. booking
29. books
30. central
 31. complication
32. crux
33. cuts
34. draw
35. event
36. excursus
37. forum
38. front
39. fundamental
40. gas

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