Usually means: Smallest in size or amount.
Definitions Related words Phrases Mentions History
We found 16 dictionaries that define the word littlest:

General (11 matching dictionaries)
  1. littlest: Merriam-Webster
  2. littlest: Collins English Dictionary
  3. littlest: Vocabulary.com
  4. Littlest, littlest: Wordnik
  5. littlest: Cambridge Advanced Learner's Dictionary
  6. littlest: Wiktionary
  7. littlest: Dictionary.com
  8. littlest: Cambridge Essential American English Dictionary
  9. littlest: Rhymezone
  10. littlest: FreeDictionary.org
  11. littlest: TheFreeDictionary.com

Business (1 matching dictionary)
  1. littlest: Legal dictionary

Computing (1 matching dictionary)
  1. littlest: Encyclopedia

Medicine (1 matching dictionary)
  1. littlest: Merriam-Webster Medical Dictionary

Miscellaneous (1 matching dictionary)
  1. littlest: Idioms

Science (1 matching dictionary)
  1. littlest: LITTLE EXPLORERS(TM) Picture Dictionary

(Note: See little as well.)

Definitions from WordNet (littlest)

adjective:  having or being distinguished by diminutive size

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