Sorry, no online dictionaries contain the exact phrase large-scale tissue.
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Reverse dictionary results:
1. massive
 2. bulk
3. general
4. gross
5. heavy
6. important
7. key
8. major
9. mass
10. scale
 11. scope
12. substantial
13. umbrella
14. wide
15. ambitious
16. across-the-board
17. ample
18. big
19. blow-up
20. broad
 21. broad-based
22. bulky
23. colossal
24. comprehensive
25. considerable
26. daunting
27. drastic
28. enormous
29. extensive
30. far-reaching
 31. forklift
32. full-blown
33. full-scale
34. full-sized
35. generalized
36. giant
37. gigantic
38. grand
39. grande
40. grandes

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You can look up the words in the phrase individually using these links:   large-scale ?   tissue ?
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