Sorry, no online dictionaries contain the exact phrase large dose.
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Reverse dictionary results:
1. drench
 2. bolus
3. massive
4. overdose
5. drenched
6. megadose
7. morning-after pill
8. batch
9. double
10. drop
 11. round
12. rounds
13. banked
14. bump
15. bumping
16. bumps
17. draft
18. drafted
19. draught
20. gray
 21. ounce
22. pastille
23. unit
24. dosage
25. dosing
26. hit
27. jit
28. lethal dose
29. lozenge
30. med
 31. pill
32. potion
33. shot
34. sievert
35. tablet
36. underdose
37. booster
38. determination
39. fic
40. fix

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You can look up the words in the phrase individually using these links:   large ?   dose ?
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larg*to search for words beginning with larg, or
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