Sorry, no online dictionaries contain the exact phrase lack of substance.
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Reverse dictionary results:
1. insubstantiality
 2. emptiness
3. void
4. hollowness
5. insignificance
6. defencelessness
7. absentmindedness
8. aimlessness
9. causelessness
10. dispassionateness
 11. dreamlessness
12. easiness
13. egolessness
14. erasure
15. forgottenness
16. friendlessness
17. groundlessness
18. heedlessness
19. ignoration
20. immoderateness
 21. impecuniosity
22. impetuousness
23. improvidence
24. impureness
25. inadvertence
26. inappositeness
27. incuriousness
28. indisposition
29. inoffensiveness
30. insipidity
 31. loneliness
32. meaninglessness
33. needlessness
34. negligibility
35. nothingness
36. passiveness
37. purposelessness
38. sacrilegiousness

You can look up the words in the phrase individually using these links:   lack ?   of ?   substance ?
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lack*to search for words beginning with lack, or
*anceto search for words ending with ance
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