Sorry, no online dictionaries contain the exact phrase first-line drug.
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Reverse dictionary results:
1. backup
 2. primary
3. reserve
4. front-line
5. auxiliary
6. first
7. frontline
8. immediate
9. second-line
10. top-of-the-line
 11. world-class
12. abirritant
13. aborticide
14. abortifacient
15. abortive
16. abstract
17. abuse
18. abused
19. abuser
20. abusers
 21. abuses
22. acetazolamide
23. acetum
24. acid
25. aconite
26. acth
27. actifed
28. active transport
29. addict
30. addicted
 31. addiction
32. addictions
33. addictive
34. addicts
35. additive
36. adiaphorous
37. adjuvant
38. adrenergic
39. aftereffect
40. agonist

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You can look up the words in the phrase individually using these links:   first-line ?   drug ?
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