Usually means: Depressants that reduce arousal, stimulation.
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We found 15 dictionaries that define the word downers:

General (10 matching dictionaries)
  1. downers: Merriam-Webster
  2. downers: Oxford Learner's Dictionaries
  3. downers: Collins English Dictionary
  4. downers: Vocabulary.com
  5. Downer's, Downers, downers: Wordnik
  6. downers: Cambridge Advanced Learner's Dictionary
  7. downers: Wiktionary
  8. downers: Dictionary.com
  9. downers: Cambridge Essential American English Dictionary
  10. Downers: Wikipedia, the Free Encyclopedia

Business (1 matching dictionary)
  1. Downers: Legal dictionary

Computing (1 matching dictionary)
  1. Downers: Encyclopedia

Medicine (2 matching dictionaries)
  1. downers: Merriam-Webster Medical Dictionary
  2. Downers: Medical dictionary

Slang (1 matching dictionary)
  1. downers: Urban Dictionary

(Note: See downer as well.)

Definitions from Wiktionary (Downer)

noun:  (slang) A negative drug trip.
noun:  (slang) A drug that has depressant qualities.
noun:  (slang) Something or someone disagreeable, dispiriting or depressing; a killjoy.
noun:  A livestock animal that has collapsed.
noun:  A form of industrial action in which workers down tools and refuse to work.
noun:  (UK, slang, obsolete) A sixpence.
noun:  A surname.
noun:  A suburb of Canberra, Australian Capital Territory, Australia, named after John Downer.
noun:  An unincorporated community in Clay County, Minnesota, United States.
▸ Also see downer


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