Sorry, no online dictionaries contain the exact phrase be significant.
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Reverse dictionary results:
1. matter
 2. count
3. be important
4. be relevant
5. carry weight
6. heed
7. proceeder
8. befriend
9. care
10. coerce
 11. compel
12. concern
13. enforce
14. entertain
15. entertaine
16. force
17. obleeged
18. perforce
19. prise
20. abet
 21. advantaged
22. adventure
23. conquest
24. discipline
25. efforce
26. effort
27. exploit
28. impose
29. induce
30. make friends
 31. motive
32. oblige
33. parting gift
34. welfare
35. adeption
36. advantage
37. ambition
38. attraction
39. beholde

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