Usually means: Irreversible cessation of brain function.
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We found 19 dictionaries that define the word brain-dead:

General (11 matching dictionaries)
  1. brain-dead: Merriam-Webster
  2. brain-dead: Oxford Learner's Dictionaries
  3. Brain-Dead, Brain-dead, brain-dead: Wordnik
  4. brain-dead: Cambridge Advanced Learner's Dictionary
  5. brain-dead: Wiktionary
  6. brain-dead: Webster's New World College Dictionary, 4th Ed.
  7. brain-dead: Dictionary.com
  8. Brain-dead: Wikipedia, the Free Encyclopedia
  9. brain-dead: TheFreeDictionary.com

Business (1 matching dictionary)
  1. brain-dead: Merriam-Webster Legal Dictionary

Computing (2 matching dictionaries)
  1. brain-dead: Free On-line Dictionary of Computing
  2. brain-dead: Encyclopedia

Medicine (3 matching dictionaries)
  1. brain-dead: Merriam-Webster Medical Dictionary
  2. online medical dictionary (No longer online)
  3. brain-dead: Medical dictionary

Slang (2 matching dictionaries)
  1. brain-dead: Green’s Dictionary of Slang
  2. Brain-dead: Urban Dictionary

(Note: See brain_death as well.)

Definitions from Wiktionary (
)
American English Definition British English Definition
adjective:  (medicine, not comparable) Having an irreversible loss of brain function and cessation of brain activity.
adjective:  (colloquial) Having no useful thoughts; stupid; ditzy.
noun:  (derogatory, informal) An unintelligent person.

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