Usually means: Surgical removal of reproductive organs.
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We found 18 dictionaries that define the word spayed:

General (15 matching dictionaries)
  1. spayed: Merriam-Webster.com
  2. spayed: Collins English Dictionary
  3. spayed: Vocabulary.com
  4. Spayed, spayed: Wordnik
  5. spayed: Cambridge Advanced Learner's Dictionary
  6. spayed: Wiktionary
  7. spayed: Dictionary.com
  8. spayed: Cambridge Essential American English Dictionary
  9. Spayed: Online Plain Text English Dictionary
  10. spayed: Rhymezone
  11. Spayed: AllWords.com Multi-Lingual Dictionary
  12. spayed: Webster's 1828 Dictionary
  13. spayed: Free Dictionary
  14. spayed: Mnemonic Dictionary
  15. spayed: Dictionary/thesaurus

Computing (1 matching dictionary)
  1. spayed: Encyclopedia

Medicine (1 matching dictionary)
  1. spayed: Medical dictionary

Slang (1 matching dictionary)
  1. Spayed: Urban Dictionary

(Note: See spay as well.)

Definitions from WordNet (spayed)

adjective:  (of a female animal) having the ovaries removed

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