Usually means: Large computers for extensive processing.
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We found 12 dictionaries that define the word mainframes:

General (10 matching dictionaries)
  1. mainframes: Merriam-Webster
  2. mainframes: Collins English Dictionary
  3. mainframes: Vocabulary.com
  4. Mainframes, mainframe's, mainframes: Wordnik
  5. mainframes: Cambridge Advanced Learner's Dictionary
  6. mainframes: Wiktionary
  7. mainframes: Dictionary.com
  8. Mainframes: Wikipedia, the Free Encyclopedia
  9. Mainframes: TheFreeDictionary.com
  10. mainframes: Cambridge Essential American English Dictionary

Computing (1 matching dictionary)
  1. Mainframes: Encyclopedia

Medicine (1 matching dictionary)
  1. Mainframes: Medical dictionary

(Note: See mainframe as well.)

Definitions from Wiktionary (mainframe)

noun:  (computer hardware) A large, powerful computer able to manage very many simultaneous tasks and communicate with very many connected terminals; used by large, complex organizations (such as banks and supermarkets) where continuously sustained operation is vital.
noun:  (computer hardware) A computer chassis that hosts and interconnects modules that perform various tasks.
noun:  The main frame of a vehicle etc., more commonly main frame.
▸ Also see mainframe


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