Usually means: Handle tasks efficiently and effectively.
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We found 3 dictionaries that define the word take care of business:

General (2 matching dictionaries)
  1. take care of business: Merriam-Webster
  2. take care of business: Wiktionary

Slang (1 matching dictionary)
  1. take care of business: Green’s Dictionary of Slang

Definitions from Wiktionary (take care of business)

verb:  (idiomatic) To successfully perform a task or set of tasks which are very important for the accomplishment of a major objective.
verb:  (idiomatic, euphemistic) To urinate or defecate.

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