Usually means: Single eye, mythical or abnormal.
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We found 6 dictionaries that define the word monophthalmus:

General (3 matching dictionaries)
  1. monophthalmus: Wordnik
  2. monophthalmus: Dictionary.com
  3. monophthalmus: Wiktionary

Medicine (3 matching dictionaries)
  1. Dorland's Illustrated Medical Dictionary (No longer online)
  2. online medical dictionary (No longer online)
  3. monophthalmus: Medical dictionary

Definitions from Wiktionary (monophthalmus)

noun:  A one-eyed person.

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