Usually means: Urine used for cleaning, tanning.
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We found 8 dictionaries that define the word chamber lye:

General (7 matching dictionaries)
  1. chamber lye: Merriam-Webster
  2. chamber-lye, chamber lye: Wordnik
  3. chamber lye: Wiktionary
  4. Chamber lye: Dictionary.com
  5. chamber-lye: Webster's 1828 Dictionary
  6. chamber lye: FreeDictionary.org
  7. Chamber lye: TheFreeDictionary.com

Slang (1 matching dictionary)
  1. chamber lye: Green’s Dictionary of Slang

Definitions from Wiktionary (chamber lye)

noun:  (now archaic, regional) Urine, especially as used for domestic or agricultural purposes.

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