Usually means: Clever, often sarcastically humorous person.
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We found 19 dictionaries that define the word wise guy:

General (18 matching dictionaries)
  1. wise guy: Longman Dictionary of Contemporary English
  2. wise guy: Merriam-Webster
  3. wise guy: Oxford Learner's Dictionaries
  4. wise guy: American Heritage Dictionary of the English Language
  5. wise guy: Collins English Dictionary
  6. wise guy: Vocabulary.com
  7. wise-guy: Wordnik
  8. wise-guy, wise guy: Cambridge Advanced Learner's Dictionary
  9. wise-guy, wise guy: Wiktionary
  10. wise guy: Infoplease Dictionary
  11. wise-guy, wise guy: Dictionary.com
  12. The Wise Guy, Wise Guy (musical), Wise guy (disambiguation), Wise guy: Wikipedia, the Free Encyclopedia
  13. wise guy: Rhymezone
  14. wise guy: FreeDictionary.org
  15. wise guy: Mnemonic Dictionary
  16. wise guy: TheFreeDictionary.com

Slang (1 matching dictionary)
  1. wise guy: Green’s Dictionary of Slang

(Note: See wise_guys as well.)

Definitions from Wiktionary (wise guy)

noun:  (informal, mildly derogatory, sarcastic or humorous) One who is insolent or flippant; one who makes jokes or perpetrates pranks.
noun:  (slang) A knowledgeable or successful sports bettor.
noun:  (US, slang) A member of the Mafia; a mobster.
noun:  (slang) A hipster.
noun:  (slang, offensive, ethnic slur) An Italian-American man.

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