Usually means: Severe form of smallpox virus.
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We found 11 dictionaries that define the word variola major:

General (7 matching dictionaries)
  1. variola major: Vocabulary.com
  2. variola major: Dictionary.com
  3. Variola major: Wikipedia, the Free Encyclopedia
  4. variola major: Rhymezone
  5. variola major: FreeDictionary.org
  6. variola major: Mnemonic Dictionary
  7. variola major: TheFreeDictionary.com

Computing (1 matching dictionary)
  1. variola major: Encyclopedia

Medicine (3 matching dictionaries)
  1. variola major: Merriam-Webster Medical Dictionary
  2. online medical dictionary (No longer online)
  3. variola major: Medical dictionary

Definitions from WordNet (variola major)

noun:  a type of smallpox virus that has a fatality rate of up to 25 percent
noun:  a highly contagious viral disease characterized by fever and weakness and skin eruption with pustules that form scabs that slough off leaving scars

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