Usually means: Confronted with significant pressure, obstacles.
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We found 6 dictionaries that define the word up against the wall:

General (4 matching dictionaries)
  1. up against the wall: Merriam-Webster
  2. up against the wall: Wiktionary
  3. up against the wall: Dictionary.com
  4. Up Against the Wall: Wikipedia, the Free Encyclopedia

Miscellaneous (1 matching dictionary)
  1. up against the wall: Idioms

Slang (1 matching dictionary)
  1. Up against the wall, up-against-the-wall: Urban Dictionary

Definitions from Wiktionary (up against the wall)

adjective:  Trapped, cornered; discommoded, discomfited; in a quandary.

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