Sorry, no online dictionaries contain the exact phrase the biggest disadvantage.
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Reverse dictionary results:
1. down
 2. lead
3. major
4. most
5. primary
6. saskatoon
7. senior
8. top
9. exploit
10. handicap
 11. harmful
12. scathing
13. squeeze
14. tree
15. worse
16. defeat
17. defeated
18. suffer
19. 22nd
20. 2nd
 21. above
22. acme
23. adjust
24. adown
25. advance
26. advancement
27. advancing
28. advantage
29. afflict
30. afflicted
 31. affordable
32. aggravate
33. aggression
34. ahead
35. airfare
36. albatross
37. alienation
38. allele
39. alpha
40. amputation

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You can look up the words in the phrase individually using these links:   the ?   biggest ?   disadvantage ?
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