Definitions from Wiktionary (run its course)
▸ verb: To come to a natural end.
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▸ verb: To come to a natural end.
Similar:
run out,
go out,
come to a close,
finish,
expire,
close,
come to an end,
terminate,
finish with,
run dry,
more...
Opposite:
▸ Words similar to run its course
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▸ Invented words related to run its course