Sorry, no online dictionaries contain the exact phrase useful substance.
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Reverse dictionary results:
1. ore
2. antibiotic
3. aloe
4. assistant
5. back
6. idle
7. lead
8. life
9. lipid
10. principle
11. reagent
12. recrement
13. recycle
14. talc
15. vain
16. vein
17. sift
18. amino
19. expansion
20. fable
21. diamond
22. render
23. saran
24. source
25. use
26. density
27. scavenge
28. scrap
29. vacuous
30. chitin
31. deposit
32. fabled
33. hemp
34. secretion
35. sublimate
36. tannin
37. tested
38. yeast
39. agar
40. lac

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You can look up the words in the phrase individually using these links:   useful ?   substance ?
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Not helpful? You might try using the wildcards * and ? to find the word you're looking for. For example, use
usef*to search for words beginning with usef, or
*anceto search for words ending with ance
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