Usually means: Most rational and mentally sound.
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We found 14 dictionaries that define the word sanest:

General (9 matching dictionaries)
  1. sanest: Merriam-Webster
  2. sanest: Collins English Dictionary
  3. sanest: Vocabulary.com
  4. sanest: Wordnik
  5. sanest: Cambridge Advanced Learner's Dictionary
  6. sanest: Wiktionary
  7. sanest: Dictionary.com
  8. sanest: Cambridge Essential American English Dictionary
  9. sanest: TheFreeDictionary.com

Business (2 matching dictionaries)
  1. sanest: Merriam-Webster Legal Dictionary
  2. sanest: Legal dictionary

Computing (1 matching dictionary)
  1. sanest: Encyclopedia

Medicine (2 matching dictionaries)
  1. sanest: Merriam-Webster Medical Dictionary
  2. sanest: Medical dictionary

(Note: See sane as well.)

Definitions from Wiktionary (SANE)

adjective:  Being in a healthy condition; not deranged; thinking rationally.
adjective:  Mentally sound; possessing a rational mind; having the mental faculties in such condition as to be able to anticipate and judge the effect of one's actions in an ordinary manner.
adjective:  Rational; reasonable; sensible.
noun:  Initialism of sexual assault nurse examiner.
noun:  (astrophysics) Ellipsis of SANE disc. A type of black hole accretion disc.
adjective:  (astrophysics) Acronym of standard and normal evolution.
▸ Also see sane

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