Definitions from Wiktionary (setback)

▸ noun:  An obstacle, delay, disadvantage, or blow (an adverse event which slows down, or prevents progress towards a desired outcome).
▸ noun:  (by extension) Any adverse event, defeat, or impediment of progress.
▸ noun:  (US) The required distance between a structure and a road.
▸ noun:  (architecture) A step-like recession in a wall.
▸ noun:  An offset to the temperature setting of a thermostat to cover a period when more or less heating is required than usual.
▸ noun:  (possibly archaic) A backset; a countercurrent; an eddy.
▸ noun:  (archaic) A backset; a check; a repulse; a relapse.

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